2019-12-11

by Erik Mosekilde (Editor), Olga Sosnovtseva (Editor), Amin Rostami-Hodjegan ( Editor) & 0 more. ISBN-13: 978-3709104170. ISBN-10: 3709104173.

He has an active program of training PhD students in Amin Rostami-Hodjegan talks with ScienceWatch.com and answers a few questions about this month's Fast Breaking Paper in the field of Pharmacology & Toxicology. Article Title: Simulation and prediction of in vivo drug metabolism in human populations from in vitro data Amin Rostami-Hodjegan. University of Sheffield, Sheffield, UK See all articles by this author. Search Google Scholar for this author.

A current lack of consensus on values of the in vivo turnover half-lives of human cytochrome P450 (CYP) enzymes places a significant limitation on the accurate prediction of changes in drug concentration-tim … Model-informed precision dosing (MIPD) has become synonymous with modern approaches for individualizing drug therapy, in which the characteristics of each patient are considered as opposed to applying a one-size-fits-all alternative. This review provides a brief account of the current knowledge, pra … amin.rostami@manchester.ac.uk Centre for Applied Pharmacokinetics Research (CAPKR), University of Manchester, Manchester, UK Certara, Blades Enterprise Centre, Sheffield, UK 2014-08-01 Title: Prediction of Intestinal First-Pass Drug Metabolism VOLUME: 8 ISSUE: 7 Author(s):Jiansong Yang, Masoud Jamei, Karen Rowland Yeo, Geoffrey T. Tucker and Amin Rostami-Hodjegan Affiliation:Simcyp Limited, Blades Enterprise Centre, John Street, Sheffield S2 4SU, United Kingdom. Keywords:First-pass metabolism, gut metabolism, CYP3A, P-glycoprotein, drug transport, well-stirred model Narciso Couto, Zubida M. Al-Majdoub, Brahim Achour, Phillip C. Wright, Amin Rostami-Hodjegan and Jill Barber Abstract ABSTRACT: There is an urgent need (recognized in FDA guidance, 2018) to optimize the dose of medicines given to patients for maximal drug efficacy and limited toxicity (precision dosing), which can be facilitated by quantitative systems pharmacology (QSP) models. Kairui Feng1, Robert H. Leary1, Michael Dunlavey1, Amin Rostami-Hodjegan1,2 1. Certara, USA; 2.

11: Chen R, Rostami-Hodjegan A, Wang H, Berk D, Shi J, Hu P. Application of a physiologically based pharmacokinetic model for the evaluation of single-point plasma phenotyping method of CYP2D6.

Amin Rostami-Hodjegan's 405 research works with 11,975 citations and 7,405 reads, including: Six years of progress in the oral biopharmaceutics area - A summary from the IMI OrBiTo project

Amin Rostami-Hodjegan. Authors. Kilian Kelly. View author publications.

Kairui Feng1, Robert H. Leary1, Michael Dunlavey1, Amin Rostami-Hodjegan1,2 1. Certara, USA; 2. University of Manchester, UK; email: kevin.feng@Certara.com USP 1 USP 2 USP 3 USP 4 Figure 1. In Vitro dissolution profiles (n=3) of nifedipine IR capsule in FaSSGF. FaSSGFst=FaSSGF at pH 1.6 with water, FaSSGFoj=FaSSGF at pH 3.4 with grapefruit juice

Redaktör, Sosnovtseva, Olga. Redaktör, Rostami-Hodjegan, Amin Lee, Jieon; Gong, Yuqing; Bhoopathy, Sid; DiLiberti, Charles E; Hooker, Andrew; Rostami-Hodjegan, Amin; Schmidt, Stephan; Suarez-Sharp, Sandra; Lukacova, Sandra Suarez-Sharp, Anders Lindahl, Tycho Heimbach, Amin Rostami-Hodjegan, Michael B Bolger, Siladitya Ray Chaudhuri and Bart Hens. Övriga författare.

Amin Rostami-Hodjegan, PhD, FCP, FAAPS, FJSSX. Amin is Director of the Centre for Applied Pharmacokinetic Research (CAPKR) at the University of Manchester. In 2007, whilst working at the University of Sheffield, he was the first full Professor appointed with the title of Systems Pharmacology. 2006-11-01 Amin Rostami-Hodjegan, Masoud Jamei, & Thomas Polasek. 2 www.certara.com Physiologically-based pharmacokinetic modeling and simulation (PBPK M&S) is a mechanistic modeling approach, actively encouraged by regulators, increasingly leveraged by biopharmaceutical companies, and used by key 2019-08-08 Amin Rostami-Hodjegan's 43 research works with 197 citations and 1,933 reads, including: Scientific Considerations to Move Towards Biowaiver for BCS Class III Drugs:How Modeling and Simulation Can Amin Rostami-Hodjegan's 405 research works with 11,975 citations and 7,405 reads, including: Six years of progress in the oral biopharmaceutics area - A summary from the IMI OrBiTo project 2019-12-11 2007-02-01 Model-informed precision dosing (MIPD) has become synonymous with modern approaches for individualizing drug therapy, in which the characteristics of each patient are considered as opposed to applying a one-size-fits-all alternative. This review provides a brief account of the current knowledge, pra … Amin Rostami-Hodjegan is Chief Scientific Officer at Certara USA, Inc. View Amin Rostami-Hodjegan’s professional profile on Relationship Science, the database of decision makers.
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Manchester School of Pharmacy, University of Manchester, UK • Following a meal, physiological changes occur that can impact upon drug absorption and elimination.

We are at the forefront of the search for solutions to some of the world's most pressing problems, seeking to be a global force for positive change. Amin Rostami-Hodjegan is Chief Scientific Officer at Certara USA, Inc. View Amin Rostami-Hodjegan’s professional profile on Relationship Science, the database of decision makers.
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Pris: 1769 kr. Häftad, 2014. Skickas inom 10-15 vardagar. Köp Biosimulation in Biomedical Research, Health Care and Drug Development av Erik Mosekilde, Olga Sosnovtseva, Amin Rostami …

Certara, USA; 2. University of Manchester, UK; email: kevin.feng@Certara.com USP 1 USP 2 USP 3 USP 4 Figure 1. In Vitro dissolution profiles (n=3) of nifedipine IR capsule in FaSSGF.

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2012 Jun 1;51(6):365-96. Jun 2012. Other authors. Penny Furness; Trevor N. Johnson; Amin Rostami-Hodjegan; Hora Soltani. See publication External link

amin.rostami@manchester.ac.uk Centre for Applied Pharmacokinetics Research (CAPKR), University of Manchester, Manchester, UK Certara, Blades Enterprise Centre, Sheffield, UK Kairui Feng1, Robert H. Leary1, Michael Dunlavey1, Amin Rostami-Hodjegan1,2 1. Certara, USA; 2. University of Manchester, UK; email: kevin.feng@Certara.com USP 1 USP 2 USP 3 USP 4 Figure 1. In Vitro dissolution profiles (n=3) of nifedipine IR capsule in FaSSGF. FaSSGFst=FaSSGF at pH 1.6 with water, FaSSGFoj=FaSSGF at pH 3.4 with grapefruit juice Adam S. Darwich, 1 Thomas M. Polasek, 2,3,4 Jeffrey K. Aronson, 5 Kayode Ogungbenro, 6 Daniel F.B. Wright, 7 Brahim Achour, 6 Jean-Luc Reny, 8,9 Youssef Daali, 8 Birgit Eiermann, 10 Jack Cook, 11 Lawrence Lesko, 12 Andrew J. McLachlan, 13 and Amin Rostami-Hodjegan 4,6 1 Logistics and Informatics in Health Care, School of Engineering Sciences in Chemistry, Biotechnology and Health … Adam S. Darwich, Kathryn Henderson, Angela Burgin, Nicola Ward, Janet Whittam, Basil J. Ammori, Darren M. Ashcroft & Amin Rostami-Hodjegan Single and multiple dose intravenous and oral pharmacokinetics of the hedgehog pathway inhibitor vismodegib in healthy female subjects Amin Rostami-Hodjegan presented new approaches for the investigation of DDIs and showed that PBPK modeling information as part of NDA submissions increased dramatically (12 fold) in the last years.